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AMINOMETHYLATION OF GUARESCHI IMIDES: SYNTHESIS OF 2,4-DIOXO-1H,5H-3,7-SPIRO[DIAZABICYCLO[3.3.1]NONANE-9,4'- PIPERIDINE]-1,5-DICARBONITRILES

Анастасия Н. Хрусталева, Константин А. Фролов, Виктор В. Доценко, Николай A. Аксенов, Инна B. Аксенова, Сергей Г. Кривоколыско
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Abstract


The aminomethylation reaction of 9-benzyl-2,4-dioxo-3,9-diazaspiro[5.5]undecane-1,5-dicarbonitrile hydrochloride in the presence of primary aliphatic amines and an excess of 37% aqueous formaldehyde led to the formation of 7-substituted 1'-benzyl-2,4-dioxo-1H,5H-spiro[3,7-diazabicyclo[3.3.1]nonane-9,4'-piperidine]-1,5-dicarbonitrile derivatives.

Authors: Anastasiya N. Khrustaleva*, Konstantin A. Frolov, Victor V. Dotsenko, Nikolai A. Aksenov, Inna V. Aksenova, Sergey G. Krivokolysko


Keywords


bispidines; 3,7-diazabicyclo[3.3.1]nonanes; 3,9-diazaspiro[5.5]undecane; 2,6-dioxopiperidine-3,5-dicarbonitrile; Guareschi imides; aminomethylation; Mannich reaction

Full Text: PDF (Russian) Supplementary File(s): Supporting information (8MB)


 

 

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