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[3+2] CYCLOADDITION-BASED ONE-POT SYNTHESIS OF 3,9-DIAZABICYCLO[4.2.1]NONANE-CONTAINING SCAFFOLD

Xiaofeng Zhang, Marc Legris, Alex M. Muthengi, Wei Zhang
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Abstract


Three-component [3+2] cycloaddition followed by reduction and lactamization has been developed as a one-pot methodology for diastereoselective synthesis of 3,9-diazabicyclo[4.2.1]nonane-containing scaffold.


Keywords


3,9-diazabicyclo[4.2.1]nonane; [3+2] cycloaddition; 1,3-dipolar cycloaddition; multicomponent reaction; one-pot synthesis

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