SYNTHESIS AND NEUROPROTECTIVE PROPERTIES OF ISOSTERIC ANALOGS OF NICOTINE

Authors

  • Е. Д. Матвеева M. V. Lomonosov State University, Moscow
  • Т. А. Подругина M. V. Lomonosov State University, Moscow
  • И. Г. Морозкин M. V. Lomonosov State University, Moscow
  • С. Е. Ткаченко Institute of Physiologically Active Substances, Russian Academy of Sciences
  • Н. С. Зефиров M. V. Lomonosov State University, Moscow

DOI:

https://doi.org/10.1007/384

Keywords:

prolinol ethers, homoprolinol ethers, neuroprotectors, calcium channel blockers, Mitsunobu reaction

Abstract

A method has been developed for the synthesis of isosteric analogs of nicotine involving ethers of S(-)-1-2-pyrrolidinemethanol and S(-)-1-2-pyrrolidineethanol based on the Mitsunobu reaction. The results of testing the synthesized compounds as calcium channel blockers are presented.

Authors: E. D. Matveeva, T. A. Podrugina, I. G. Morozkin, S. E. Tkachenko, and N. S. Zefirov.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (10), pp 1149-1153

http://link.springer.com/article/10.1023/A%3A1002856330054

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Published

2013-03-11

Issue

No. 10 (2000)

Section

Original Papers