SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF NEW FUROCOUMARIN DERIVATIVES

Abstract

Synthesis of linear and angular furocoumarins and difurocoumarins has been carried out starting from substituted coumarins and phenyl acetylene leading to the target compounds via styrylcoumarin intermediates. The average yields are higher than those reported before. Newly synthesized furocoumarin and difurocoumarin derivatives were evaluated for inhibition of cell proliferation of human breast carcinoma, human gastric carcinoma, and human lung cancer, exhibiting antiproliferative activity. New difurocoumarin derivative 4-methyl-6,9-diphenyl-2H-difuro[3,2-f:2',3'-h]chromen-2-one exhibited the highest inhibition of cell proliferation on all cell lines.