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PRIVILEGED HETEROCYCLES: BIOACTIVITY AND SYNTHESIS OF 1,9-DIAZASPIRO[5.5]UNDECANE-CONTAINING COMPOUNDS

Daniel Blanco-Ania, Rik Heus, Floris P. J. T. Rutjes
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Abstract


This review discusses the biological activity and synthesis of 1,9-diazaspiro[5.5]undecanes, including those ring-fused with arenes and heteroarenes and/or containing a carbonyl group at position 2. These compounds could be used for the treatment of obesity, pain, as well as various immune system, cell signaling, cardiovascular, and psychotic disorders.

Keywords


1,9-diazaspiro[5.5]undecane; 1,9-diazaspiro[5.5]undecan-2-one; spiro dipiperidines; obesity; pain treatment

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