SYNTHESIS AND CYTOTOXICITY OF SILYL- AND CARBONYL-SUBSTITUTED ISOXAZOLES

Abstract

We have obtained various diphenylmethylsilyl- and carbonyl-substituted isoxazoles by [2+3]-dipolar cycloaddition of nitrile oxides to diphenylmethylsilyl-, hydroxymethyl-, methoxymethyl-, and ethoxycarbonylacetylenes. We have observed that the isoxazoles obtained exhibit moderate cytotoxicity relative to the HT-1080 and MG-22A cell lines. The highest activity level is displayed by 3-methyl-5-diphenylmethylsilylisoxazole.

Authors: E. Lukevics, P. Arsenyan, and I. Shestakova.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (10), pp 1226-1231

http://link.springer.com/article/10.1023/A%3A1002833119576