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SYNTHESIS OF POLYFUNCTIONALIZED 1,1'-( α,ω -ALKANEDIYL)BIS(1,2,3,4-TETRAHYDROPYRIDINES)

Наталья Николаевна Гибадуллина, Дилара Роландовна Латыпова, Тимур Римович Нугуманов, Леонид Васильевич Спирихин, Владимир Анатольевич Докичев
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Abstract


A one-pot reaction was developed for the synthesis of polyfunctionalized 1,1'-(α,ω-alkanediyl)bis(1,2,3,4-tetrahydropyridines) in 28–69% yields on the basis of a three-component reaction between 1,3-dicarbonyl compounds, aqueous 33% solution of formaldehyde, and α,ωdiamines.

 


Keywords


acetoacetic ester, acetylacetone, 1,1'-(α,ω-alkanediyl)bis(1,2,3,4-tetrahydropyridines), α,ω-diamines, formaldehyde, multi-component reaction

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