SYNTHESIS OF POLYFUNCTIONALIZED 1,1'-( α,ω -ALKANEDIYL)BIS(1,2,3,4-TETRAHYDROPYRIDINES)
DOI:
https://doi.org/10.1007/3937Keywords:
acetoacetic ester, acetylacetone, 1, 1'-(α, ω-alkanediyl)bis(1, 2, 3, 4-tetrahydropyridines), α, ω-diamines, formaldehyde, multi-component reactionAbstract
A one-pot reaction was developed for the synthesis of polyfunctionalized 1,1'-(α,ω-alkanediyl)bis(1,2,3,4-tetrahydropyridines) in 28–69% yields on the basis of a three-component reaction between 1,3-dicarbonyl compounds, aqueous 33% solution of formaldehyde, and α,ωdiamines.
