Open Access Open Access  Restricted Access Subscription Access

NONCATALYTIC DESTRUCTION OF 5-ACYLCOMANIC ACID ESTERS IN THE PRESENCE OF 2-METHYLINDOLES AS A NEW METHOD FOR THE SYNTHESIS OF INDOLYLCHALCONES

Дмитрий Львович Обыденнов, Екатерина О. Панькина, Вячеслав Я. Сосновских
Cover Image

Abstract


Ethyl esters of 5-acylcomanic acids reacted with 2-methylindoles in 3:1 propanol–water mixture in the absence of catalyst, resulting in pyrone ring opening and destruction of the molecular framework and leading to trans-indolylchalcones in 52–70% yields.

Dmitrii L. Obydennov*, Ekaterina O. Pan’kina, Vyacheslav Ya. Sosnovskikh

 

 


Keywords


chalcones; indoles; 4-pyrones; alkenylation; ring destruction

Full Text: PDF (Russian) Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv