THE ADDITION OF Β-KETOACIDS TO 4-(TRIFLUOROMETHYL)PYRIMIDIN- 2(1<i>Н</i>)-ONES WITH DECARBOXYLATION: AN EFFECTIVE METHOD FOR THE SYNTHESIS OF 4-(2-OXOALKYL)-6-(TRIFLUOROMETHYL)-3,4-DIHYDROPYRIMIDIN-2-ONES

Authors

  • Виктор Ткачук
  • Сергей Мельников
  • Владимир Сукач
  • Михаил Владимирович Вовк

DOI:

https://doi.org/10.1007/3995

Keywords:

β-ketoacids, 4-(2-oxoalkyl)-6-(trifluoromethyl)-3, 4-dihydropyrimidin-2-ones, 4-(trifluoromethyl)pyrimidin-2(1Н)-ones, Michael addition.

Abstract

β-Ketoacids reacted with 4-(trifluoromethyl)pyrimidin-2(1Н)-ones according to the mechanism of Michael addition–decarboxylation, forming 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones.

 

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Published

2017-11-27

Issue

Vol. 53 No. 10 (2017)

Section

Original Papers