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THE ADDITION OF Β-KETOACIDS TO 4-(TRIFLUOROMETHYL)PYRIMIDIN- 2(1Н)-ONES WITH DECARBOXYLATION: AN EFFECTIVE METHOD FOR THE SYNTHESIS OF 4-(2-OXOALKYL)-6-(TRIFLUOROMETHYL)-3,4-DIHYDROPYRIMIDIN-2-ONES

Виктор Ткачук, Сергей Мельников, Владимир Сукач, Михаил Владимирович Вовк
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Abstract


β-Ketoacids reacted with 4-(trifluoromethyl)pyrimidin-2(1Н)-ones according to the mechanism of Michael addition–decarboxylation, forming 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones.

 


Keywords


β-ketoacids, 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones, 4-(trifluoromethyl)pyrimidin-2(1Н)-ones, Michael addition.

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