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AN EFFICIENT AND FACILE SYNTHESIS OF D-CYCLOSERINE SUBSTANTIALLY FREE FROM POTENTIAL IMPURITIES

Pramod Kumar
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Abstract


An efficient and facile synthesis of D-cycloserine has been developed from D-serine with 61% overall yield employing protection-deprotection strategy. Different parameters affecting the impurities content and yield of D-cycloserine have been studied. Mild reaction conditions provided the product with remarkable purity (>99%) and high stability.

 


Keywords


D-cycloserine, mixed anhydride, carboxybenzyl protecting group, deprotection, impurities.

Full Text: PDF Supplementary File(s): Supporting information (2MB)


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv