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SYNTHESIS OF NEW PYRROLO[3,2-l]ACRIDINONES AND PYRROLO[3,2-c][1,8]NAPHTHYRIDINONES BY CONDENSATION OF METHOXYBENZENES OR PHENOLS WITH ISOBUTYRIC ALDEHYDE AND o-AMINONITRILES

Юлия Сергеевна Рожкова, Татьяна Степановна Вшивкова, Вячеслав Владимирович Морозов, Владимир Евгеньевич Жуланов, Алексей Аркадьевич Горбунов, Юрий Владимирович Шкляев
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Abstract


A reaction of methoxybenzenes or phenols with isobutyric aldehyde and 2-amino-5-nitro- or 2-amino-4-chlorobenzonitriles in concentrated H2SO4 medium was used for the preparation of new pyrrolo[3,2-l]acridinone derivatives. Analogous reactions using 2amino-3-pyridinecarbonitrile enabled the synthesis of previously unknown benzo[b]pyrrolo[3,2c][1,8]naphthyridinones.

 


Keywords


o-aminonitriles, arenes, isobutyric aldehyde, pyrrolo[3,2-l]acridinone, pyrrolo[3,2-c][1,8]naphthyridinone, sulfuric acid, aza-Michael reaction, dearomatization, domino reaction.

Full Text: PDF (Russian) Supplementary File(s): Рисунок 1 (62KB) Рисунок 2 (54KB) Рисунок 3 (46KB) Графический реферат (42KB)


 

 

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