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CHEMOSELECTIVE IODINATION OF 6-SUBSTITUTED IMIDAZO[1,2-a]PYRIDINE

Chunshen Zhao, Fei Li, Shuo Yang, Li Liu, Zhuyan Huang, Huifang Chai
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Abstract


3- and 8-Iodoimidazo[1,2-a]pyridines were synthesized from imidazo[1,2-a]pyridine under different substitution conditions. The molecular electrostatic potential calculations were performed to investigate the chemoselectivity of the substitution reaction. The molecular structures of the target compounds were characterized by single crystal X-ray diffraction analysis.


Keywords


imidazo[1,2-a]pyridine; heteroaryl iodides; synthesis; X-ray diffraction.

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