5-ARYL-2-FURALDEHYDES IN THE SYNTHESIS OF TETRAHYDROPYRIMIDINONES BY BIGINELLI REACTION

Andriy R. Vakhula; Yuriy I. Horak; Roman Z. Lytvyn; Alexandra I. Lesyuk; Vasyl Kinzhybalo; Fedor I. Zubkov; Mykola D. Obushak

doi:10.1007/4124

5-ARYL-2-FURALDEHYDES IN THE SYNTHESIS OF TETRAHYDROPYRIMIDINONES BY BIGINELLI REACTION

Andriy R. Vakhula, Yuriy I. Horak, Roman Z. Lytvyn, Alexandra I. Lesyuk, Vasyl Kinzhybalo, Fedor I. Zubkov, Mykola D. Obushak

Abstract

5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with ethyl acetoacetate or acetylacetone and (thio)urea in the presence of FeCl₃·6H₂O as a catalyst. A series of ethyl 4-(5-aryl-2-furyl)-6-methyl-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylates was obtained.

Keywords

5-aryl-2-furaldehydes; pyrimidine derivatives; tetrahydropyrimidines; Biginelli reaction; crystal structure; multicomponent reactions.

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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