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5-ARYL-2-FURALDEHYDES IN THE SYNTHESIS OF TETRAHYDROPYRIMIDINONES BY BIGINELLI REACTION

Andriy R. Vakhula, Yuriy I. Horak, Roman Z. Lytvyn, Alexandra I. Lesyuk, Vasyl Kinzhybalo, Fedor I. Zubkov, Mykola D. Obushak
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Abstract


5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with ethyl acetoacetate or acetylacetone and (thio)urea in the presence of FeCl3·6H2O as a catalyst. A series of ethyl 4-(5-aryl-2-furyl)-6-methyl-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylates was obtained.


Keywords


5-aryl-2-furaldehydes; pyrimidine derivatives; tetrahydropyrimidines; Biginelli reaction; crystal structure; multicomponent reactions.

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