SODIUM HYDROGEN SULFATE AS A CATALYST FOR THE SYNTHESIS OF  N ,4-DIARYL-6-METHYL-1-METHYL(PHENYL)-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXAMIDES  VIA  THE BIGINELLI REACTION

Vladimir L. Gein; Tatiana M. Zamaraeva; Maksim V. Dmitriev

doi:10.1007/4138

SODIUM HYDROGEN SULFATE AS A CATALYST FOR THE SYNTHESIS OF N,4-DIARYL-6-METHYL-1-METHYL(PHENYL)-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXAMIDES VIA THE BIGINELLI REACTION

Vladimir L. Gein, Tatiana M. Zamaraeva, Maksim V. Dmitriev

Abstract

N,4-Diaryl-6-methyl-1-methyl(phenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides were synthesized in three-component reaction of N-aryl-3-oxobutanamides, aromatic aldehyde, and N-methylthiourea (N-phenylthiourea) in ethanol in the presence of nontoxic, cheap sodium hydrogen sulfate as a catalyst. Products were obtained in moderate to high yields.

Keywords

aromatic aldehyde, keto amide, N-methylthiourea, N-phenylthiourea, 2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, Biginelli reaction.

Full Text: PDF (Russian) Restricted Access

Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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