

NEW METHOD FOR THE SYNTHESIS OF 2-HETARYL-2-(1-R-PYRROLIDIN-2-YLIDENE)ACETONITRILES

Abstract
New method was developed for the synthesis of 2-hetaryl-2-(1-R-pyrrolidin-2-ylidene)acetonitriles by using a three-component condensation of hetarylacetonitrile, phosphorus oxychloride, and 1-R-pyrrolidin-2-one. This method is applicable to the synthesis of β-enaminonitriles containing azoles and six-membered azaheteroaromatic rings at the α-position relative to the nitrile group.
Authors: Olena A. Kuleshova*, Olga V. Khilya, Yulian M. Volovenko
Keywords
hetarylacetonitriles; 2-hetaryl-2-(1-R-pyrrolidin-2-ylidene)acetonitriles; pyrrolinium salts; condensation reactions; three-component reaction
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv