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NEW METHOD FOR THE SYNTHESIS OF 2-HETARYL-2-(1-R-PYRROLIDIN-2-YLIDENE)ACETONITRILES

Елена А. Кулешова, Ольга В. Хиля, Юлиан М. Воловенко
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Abstract


New method was developed for the synthesis of 2-hetaryl-2-(1-R-pyrrolidin-2-ylidene)acetonitriles by using a three-component condensation of hetarylacetonitrile, phosphorus oxychloride, and 1-R-pyrrolidin-2-one. This method is applicable to the synthesis of β-enaminonitriles containing azoles and six-membered azaheteroaromatic rings at the α-position relative to the nitrile group.

Authors: Olena A. Kuleshova*, Olga V. Khilya, Yulian M. Volovenko


Keywords


hetarylacetonitriles; 2-hetaryl-2-(1-R-pyrrolidin-2-ylidene)acetonitriles; pyrrolinium salts; condensation reactions; three-component reaction

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