SYNTHESIS AND TUBERCULOSTATIC ACTIVITY OF FUNCTIONALIZED PYRAZOLES DERIVED FROM (TRIFLUOROMETHYL)PYRAZOLE CONTAINING A HYDRAZONE GROUP

Authors

  • Денис Назарович Бажин Институт органического синтеза им. И. Я. Постовского УрО РАН
  • Юлия Сергеевна Кудякова
  • Александра Яновна Оноприенко
  • Павел Александрович Слепухин
  • Янина Валерьевна Бургарт
  • София Сергеевна Борисевич
  • Сергей Леонидович Хурсан
  • Виктор Иванович Салоутин

DOI:

https://doi.org/10.1007/4202

Keywords:

hydrazones, pyrazole, thiosemicarbazides, condensation.

Abstract

The condensation of 5-(1-hydrazinylideneethyl)-3-(trifluoromethyl)-1H-pyrazole with trimethyl orthoacetate, dimethylformamide
dimethyl acetal, and aryl thioisocyanates resulted in a series of functionalized pyrazoles and their tuberculostatic activity was studied.

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Published

2018-01-18

Issue

Vol. 53 No. 12 (2017)

Section

Original Papers