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INTERACTION OF CONDENSED TETRAHYDROPYRIDO- [4,3-d]PYRIMIDIN-4-ONES WITH DEHYDROBENZENE – SYNTHESIS OF 6-VINYLPYRIMIDINONES FUSED WITH FIVE-MEMBERED HETEROCYCLE CONTAINING TWO OR THREE HETEROATOMS

Леонид Г. Воскресенский, Наталья И. Гуранова, Татьяна Н. Борисова, Елена А. Сорокина, Алексей В. Варламов, Александр В. Аксенов
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Abstract


The reaction between dehydrobenzene and tetrahydropyrido[4,3-d]pyrimidin-4-ones condensed with isoxazole, thiazole, thiadiazole, or triazole rings resulted in Hofmann cleavage of the tetrahydropyridine moiety with the formation of 6-vinyl-substituted pyrimidones fused with the corresponding azole rings.

Keywords


arynes, azole ring, dehydrobenzene, pyridopyrimidinones, vinyl-substituted pyrimidinones, annulation, Hofmann cleavage.

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