1,4-DIAZABICYCLO[2.2.2]OCTANE IN THE SYNTHESIS OF PIPERAZINE DERIVATIVES (MICROREVIEW)

Abstract

A new methodology for the synthesis of piperazine derivatives is
analyzed, starting from 1,4-diazabicyclo[2.2.2]octane as the source of
piperazine ring and quaternary ammonium salts obtained from
1,4-diazabicyclo[2.2.2]octane as synthetic intermediates. This microreview
summarizes literature data published over the last 15 years.