7-ALKYLAMINO-6-NITROTETRAZOLO[1,5- a ]PYRIMIDINES AS PRECURSORS OF ANOMALOUS NUCLEOSIDES AND HETEROCYCLES WITH POTENTIAL ANTISEPTIC ACTIVITY

Константин В. Саватеев; Виктор В. Федотов; Евгений Н. Уломский; Владимир Л. Русинов

doi:10.1007/4209

7-ALKYLAMINO-6-NITROTETRAZOLO[1,5-a]PYRIMIDINES AS PRECURSORS OF ANOMALOUS NUCLEOSIDES AND HETEROCYCLES WITH POTENTIAL ANTISEPTIC ACTIVITY

Константин В. Саватеев, Виктор В. Федотов, Евгений Н. Уломский, Владимир Л. Русинов

Abstract

A method was developed for the synthesis of 7-alkylamino-5-methyl-6-nitrotetrazolo[1,5-a]pyrimidines from the readily available 5-methyl-6-nitrotetrazolo[1,5-a]pyrimidin-7(4H)-one by using a sequence of chlorodeoxygenation and amination reactions. The chlorinated intermediate formed along this route was isolated and characterized as 7-chloro-5-methyl-6-nitrotetrazolo[1,5-a]pyrimidine.

Authors: Konstantin V. Savateev*, Victor V. Fedotov, Eugeny N. Ulomskiy, Vladimir L. Rusinov

Keywords

tetrazolopyrimidines; adenosine receptors; azide-tetrazole tautomerism; chlorodeoxygenation; sepsis

Full Text: PDF (Russian) Open Access

Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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