

A STUDY OF PLANT COUMARINS. 16. SYNTHESIS AND TRANSFORMATIONS OF 7-ALKYNYLCOUMARINS

Abstract
7-Alkynyl-substituted coumarins were synthesized by a Sonogashira reaction of 6-substituted 7-(trifluoromethylsulfonyloxy)coumarins with terminal acetylenes. The reaction of 7-ethynyl-substituted coumarins with azidobenzoic acids in the presence of copper(II) sulfate and sodium ascorbate was used to synthesize the respective 7-[(1-carboxyphenyl)-1H-1,2,3-triazol-4-yl]coumarins.
Authors: Alla V. Lipeeva, Elvira E. Shults*
Keywords
arylalkynes; coumarins; 1,2,3-triazoles; CuААС reaction; Sonogashira reaction
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv