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SYNTHESIS OF FUNCTIONALIZED TRIAZOLO[1,5-a]PYRIMIDINE DERIVATIVES

Наталья В. Чечина, Надежда Н. Колос, Ирина В. Омельченко, Владимир И. Мусатов
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Abstract


New triazolo[1,5-a]pyrimidines containing aroyl and acetyl or ester groups in the pyrimidine ring were synthesized in a process related to the Biginelli-like reaction, using hydrates of arylglyoxals, β-dicarbonyl compounds, and 1H-1,2,4-triazol-5-amine. Reaction was carried out in either sequential or one-pot procedure.

Keywords


acetoacetic ester; acetylacetone; arylglyoxal hydrates; 4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidines; 1H-1,2,4-triazol-5-amine; Biginelli-like reaction; three-component condensation

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