

SYNTHESIS OF FUNCTIONALIZED TRIAZOLO[1,5-a]PYRIMIDINE DERIVATIVES

Abstract
New triazolo[1,5-a]pyrimidines containing aroyl and acetyl or ester groups in the pyrimidine ring were synthesized in a process related to the Biginelli-like reaction, using hydrates of arylglyoxals, β-dicarbonyl compounds, and 1H-1,2,4-triazol-5-amine. Reaction was carried out in either sequential or one-pot procedure.
Keywords
acetoacetic ester; acetylacetone; arylglyoxal hydrates; 4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidines; 1H-1,2,4-triazol-5-amine; Biginelli-like reaction; three-component condensation
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv