THREE-COMPONENT HETERO-DOMINO CYCLIZATION AND COPPER-CATALYZED DOUBLE A 3 -COUPLING REACTION OF ETHANE-1,2-DIAMINES, FORMALDEHYDE, AND ALKYNES TO AFFORD 1,3-DIPROPARGYLIMIDAZOLIDINES

Lu Sun; Mengying Wu; Xi Huang; Jiayi Wang; Gonghua Song

doi:10.1007/4365

THREE-COMPONENT HETERO-DOMINO CYCLIZATION AND COPPER-CATALYZED DOUBLE A³-COUPLING REACTION OF ETHANE-1,2-DIAMINES, FORMALDEHYDE, AND ALKYNES TO AFFORD 1,3-DIPROPARGYLIMIDAZOLIDINES

Lu Sun, Mengying Wu, Xi Huang, Jiayi Wang, Gonghua Song

Abstract

A novel and efficient approach to the synthesis of 1,3-dipropargylimidazolidines via a hetero-domino cyclization and copper-catalyzed double A³-coupling reaction of ethane-1,2-diamines, formaldehyde, and alkynes has been reported. The transformation provides a useful method for the synthesis of imidazolidine derivatives.

Keywords

1,3-dipropargylimidazolidines; A3-coupling; copper catalysis; cyclization; hetero-domino reaction; three-component reaction

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Supplementary File(s): Supporting information (3MB)

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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