CYCLOCONDENSATION OF 3-AMINO-1,2,4-TRIAZOLES WITH ESTERS OF SUBSTITUTED CINNAMIC ACIDS AND AROMATIC UNSATURATED KETONES

Authors

  • В. В. Липсон Ukrainian Scientific-Research Institute of Pharmacotherapy of Endocrine Diseases, Kharkov
  • С. М. Десенко V. N. Karazin Kharkov National University
  • В. Д. Орлов V. N. Karazin Kharkov National University
  • О. В. Шишкин Institute of Single Crystals
  • М. Г. Широбокова Ukrainian Scientific-Research Institute of Pharmacotherapy of Endocrine Diseases, Kharkov
  • В. Н. Черненко Ukrainian Scientific-Research Institute of Pharmacotherapy of Endocrine Diseases, Kharkov
  • Л. И. Зиновьева V. N. Karazin Kharkov National University

DOI:

https://doi.org/10.1007/437

Keywords:

3-amino-1, 2, 4-triazoles, arylidenemethyl ketones, 7-phenyl-4, 5, 6, 7-tetrahydro-1, 4-triazolo[1, 5-a]pyrimidin-5-one, esters of cinnamic acids, X-ray diffraction analysis

Abstract

We have studied the reactions of 3-amino, 3,5-diamino-, and 3-amino-5-trifluoromethyl-1,2,4-triazole with esters of substituted cinnamic acids and aromatic unsaturated ketones; we have established the directionality of formation of the tetrahydrooxopyrimidine ring. We have carried out hydrolysis and hydrazinolysis of 7-phenyl-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidin-5-one. We have conducted an X-ray diffraction study of isopropylidene hydrazide of 3-(5-amino-1,2,4-triazol-1-yl)-3-phenylpropionic acid.

Authors: V. V. Lipson, S. M. Desenko, V. D. Orlov, O. V. Shishkin, M. G. Shirobokova, V. N. Chernenko, and L. I. Zinov'eva.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (11), pp 1329-1335

http://link.springer.com/article/10.1023/A%3A1017531803879

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Published

2013-03-27

Issue

No. 11 (2000)

Section

Original Papers