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SYNTHESIS AND EVALUATION OF SOME NOVEL 3-HETARYLINDOLE DERIVATIVES AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS

Ahmed El-Mekabaty, Hamed M. El-Shora
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Abstract


In a continuation of our program to develop a new class of antimicrobial and antioxidant agents, 13 novel 3-substituted indole derivatives incorporating biologically active heterocycles were synthesized and evaluated for their in vitro antimicrobial activity. Among the synthesized compounds, 3-(7H-imidazo[2,1-c][1,2,4]triazol-5-yl)-1H-indole showed activity against E. faecalis equal to that of ampicillin and 50% higher activity than ampicillin against S. aureus and B. subtilis. Also, 3-(7H-imidazo[2,1-c][1,2,4]triazol-5-yl)-1Hindole was found to exhibit strong in vitro antifungal activity against Candida albicans, Aspergillus niger, and Penicillium sp. The antioxidant activity of the obtained indole derivatives was also studied using 2,2'-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3ethylbenzothiazoline-6-sulfonic acid).


Keywords


benzochromenes; benzofurans; furans; indole derivatives; antimicrobial activity; antioxidant activity

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