MICROWAVE-ASSISTED SYNTHESIS OF NOVEL BENZODIFURAN-BASED BIS(<i>N</i>-(HET)ARYLTHIAZOL-2-AMINE) DERIVATIVES AND THEIR ANTIBACTERIAL AND ANTIMYCOBACTERIAL ACTIVITIES

Authors

  • Baba N. H. Kumar Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad-500085, Telangana, India Chemveda Life Sciences India Pvt Ltd, I.D.A. Uppal, Hyderabad-500039, Telangana, India
  • ASHOK D osmania university
  • Ananda Rao Boddu Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, Telangana, India.
  • Sarasija Madderla Department of Chemistry, Satavahana University, Karimnagar, Telangana, 505001, India.
  • Murthy N. Y. S. Department of Chemistry, Anurag group of Institutions, Hyderabad, Telangana, 500088, India.

DOI:

https://doi.org/10.1007/4380

Keywords:

benzodifuran, thiazole, antibacterial, antimycobacterial, microwave irradiation.

Abstract

A new series of 4,4'-(3,5-diphenethylbenzo[1,2-b:5,4-b']difuran-2,6-diyl)bis(N-(het)arylthiazol-2-amine) derivatives have been synthesized from 1,1'-(3,5-diphenethylbenzo[1,2-b:5,4-b']difuran-2,6-diyl)diethanone O,O'-diacetyl dioxime and substituted isothiocyanates under conventional and microwave irradiation conditions. The obtained products were subjected to in vitro antibacterial and antimycobacterial activity tests. Some of the compounds exhibited noteworthy antibacterial activity against Bacillus subtilis (+ve) and Pseudomonas aeruginosa (-ve) strains and antimycobacterial activity against Mycobacterium bovis strain.

Author Biography

ASHOK D, osmania university

Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, Telangana, India.

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Published

2018-07-25

Issue

Vol. 54 No. 6 (2018)

Section

Original Papers