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USE OF HYPERVALENT IODINE IN THE SYNTHESIS OF ISOMERIC DIHYDROOXAZOLES

Claudia Carlucci, Arianna Tota, Marco Colella, Giuseppe Romanazzi, Guy J. Clarkson, Renzo Luisi, Leonardo Degennaro
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Abstract


A convenient synthesis of 2- and/or 3-oxazolines has been developed depending on the structure and stereochemistry of the starting amino alcohol. PhI(OAc)2 acted as oxidant on the intermediate imine, as supported by NMR investigation. The findings demonstrate a new route providing access to unusual 3-oxazolines.


Keywords


hypervalent iodine; 2-oxazolines; 3-oxazolines; NMR studies; stereoselective synthesis

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