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CONDENSATION OF 2-AMINOMETHYLANILINE WITH ALDEHYDES AND KETONES FOR THE FAST ONE-POT SYNTHESIS OF A LIBRARY OF 1,2,3,4-TETRAHYDROQUINAZOLINES UNDER FLOW CONDITIONS

Francesca Mangiavacchi, Leonardo Mollari, Luana Bagnoli, Francesca Marini, Claudio Santi
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Abstract


A new eco-friendly and reliable methodology for the synthesis of 1,2,3,4-tetrahydroquinazolines is proposed. This simple protocol was tested for the continuous synthesis of a small library of 1,2,3,4-tetrahydroquinazoline derivatives demonstrating good versatility and applicability.


Keywords


aldehydes, alumina, tetrahydroquinazoline, flow chemistry, green chemistry.

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