CONDENSATION OF 2-AMINOMETHYLANILINE WITH ALDEHYDES AND KETONES FOR THE FAST ONE-POT SYNTHESIS OF A LIBRARY OF 1,2,3,4-TETRAHYDROQUINAZOLINES UNDER FLOW CONDITIONS

Authors

  • Francesca Mangiavacchi
  • Leonardo Mollari
  • Luana Bagnoli
  • Francesca Marini
  • Claudio Santi Department of Pharmaceutical Sciences University of Perugia

DOI:

https://doi.org/10.1007/4463

Keywords:

aldehydes, alumina, tetrahydroquinazoline, flow chemistry, green chemistry.

Abstract

A new eco-friendly and reliable methodology for the synthesis of 1,2,3,4-tetrahydroquinazolines is proposed. This simple protocol was tested for the continuous synthesis of a small library of 1,2,3,4-tetrahydroquinazoline derivatives demonstrating good versatility and applicability.

Published

2018-06-04