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AQUEOUS N-METHYLMORPHOLINE N-OXIDE AS A NEW MEDIUM FOR ALKYLATION OF PYRAZOLES

Асмик Нверовна Хачатрян, Ашхаруи Г. Алексанян, Ани Г. Асратян, Саркис С. Айоцян, Гехецик Б. Закарян, Геворг Г. Данагулян, Оганес С. Аттарян
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Abstract


It is shown that alkylation of pyrazoles with (E)/(Z)-1,3-dichlorobut-2-enes can be carried out in an alkaline aqueous medium in the presence of N-methylmorpholine N-oxide. In some cases, this technique may substitute phase-transfer catalysis. Conformational analysis of the reaction products showed that a mixture of (E)/(Z) isomers is formed in a ratio of 9:1.

Keywords


1,3-dichlorobut-2-ene, N-methylmorpholine N-oxide, pyrazole, alternative reaction medium, phase-transfer catalysis.

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