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ACHIEVEMENTS IN THE SYNTHESIS OF CYCLOOCTYNES FOR RING STRAIN-PROMOTED [3+2] AZIDE-ALKYNE CYCLOADDITION
Abstract
The aim of this review is to present the entire range of cyclooctynes that are currently known in the literature. We provide a generalized and systematic overview of methods for their synthesis and consider the applications of cyclooctynes for the purposes of molecular biology and cellular engineering. The importance of cyclooctynes for [3+2] azide-alkyne cycloaddition is demonstrated, as the high reactivity of cyclooctynes allows to perform this reaction under mild conditions without a catalyst.
Authors:
Evgeny G. Chupakhin, Mikhail Yu. Krasavin
Keywords
cyclooctynes; [3+2] azide-alkyne cycloaddition reactions; fluorescence microscopy; in situ click chemistry; SPAAC reactions; visualization of living cell.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv