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Pd/Cu-ASSISTED C–S ACTIVATION AND N–H INSERTION: HIGHLY VERSATILE SYNTHESIS OF 2-AMINOPYRIMIDINES FROM 3,4-DIHYDROPYRIMIDINE-2(1H)-THIONES

Hina Mathur, Mohammed Shahrukh Khan Zai, Poonam Khandelwal, Neetu Kumari, Ved Prakash Verma, Dinesh Kumar Yadav
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Abstract


A method for the synthesis of 2-aminopyrimidines from readily available 3,4-dihydropyrimidine-2(1H)-thiones via a palladium-assisted C–S activation and N–H insertion reaction is developed. The process provides an access to a variety of highly diverse 2-aryl(alkyl)aminopyrimidine adducts in good yields.

Keywords


2-aminopyrimidines; Biginelli reaction; C–S activation; N–H insertion

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