[1,2,4]TRIAZINO[2,3-с]QUINAZOLINES 3*. STRUCTURE AND ANTICANCER ACTIVITY OF PRODUCTS OBTAINED FROM REACTION OF 3-(2-AMINOPHENYL)-6-R-1,2,4-TRIAZIN-5(2H)-ONES WITH ARYL ISO(THIO)CYANATES

Abstract

Reactions of 3-(2-aminophenyl)-6-R-1,2,4-triazin-5(2H)-ones with aryl isocyanates and aryl isothiocyanates were studied by using solvents of various nature, as well as varying the temperature regime and process duration. The series of synthesized compounds was shown to exhibit pronounced cytostatic activity with respect to specific cell lines of melanoma, non-small cell lung cancer, kidney cancer, and cancer of central nervous system.