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RECENT ADVANCES IN THE SYNTHESIS AND REACTIVITY OF SPIRO-EPOXYOXINDOLES

Vittorio Pace, Serena Monticelli, Laura Castoldi, Saad Touqeer, Margherita Miele, Ernst Urban
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Abstract


Spiro-epoxyoxindoles containing an unsubstituted methylene fragment in the oxirane ring are excellent building blocks in organic synthesis due to the high reactivity conferred by the three-membered oxygenated cycle. In this minireview, a concise survey of the methods of their synthesis and examples of reactivity with carbon and nitrogen nucleophiles is presented, with a particular focus on the stereochemical aspects. The review covers the literature for the last twenty years.


Keywords


epoxides, isatins, spiro compounds, Friedel–Crafts reaction, nucleophilic addition.

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