

RECENT ADVANCES IN THE SYNTHESIS AND REACTIVITY OF SPIRO-EPOXYOXINDOLES

Abstract
Spiro-epoxyoxindoles containing an unsubstituted methylene fragment in the oxirane ring are excellent building blocks in organic synthesis due to the high reactivity conferred by the three-membered oxygenated cycle. In this minireview, a concise survey of the methods of their synthesis and examples of reactivity with carbon and nitrogen nucleophiles is presented, with a particular focus on the stereochemical aspects. The review covers the literature for the last twenty years.
Keywords
epoxides, isatins, spiro compounds, Friedel–Crafts reaction, nucleophilic addition.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv