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MICROWAVE-ASSISTED EFFICIENT AND CONVENIENT ONE-POT SYNTHESIS OF NOVEL 3-(4-AMINOTHIENO[2,3-d]PYRIMIDIN-5-YL)COUMARINS UNDER SOLVENT-FREE CONDITIONS

Srikrishna Devulapally
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Abstract


An efficient green synthesis of novel 3-(4-aminothieno[2,3-d]pyrimidin-5-yl)coumarins has been developed. One-pot reaction of 3-acetylcoumarin, malononitrile, and elemental sulfur, catalyzed by L-proline, resulted in the formation of thiophene derivatives, which were used as precursors for the synthesis of 3-(4-aminothieno[2,3-d]pyrimidin-5-yl)coumarins. Target compounds were prepared by a one-pot method or stepwise, and NH4OAc was exploited as a reagent and molten salt. Microwave irradiation method was successfully applied to afford the products in excellent yields.


Keywords


ammonium acetate, coumarin, thieno[2,3-d]pyrimidine, green synthesis, microwave irradiation, solvent-free

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