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ONE-POT SYNTHESIS OF [4-(tert-BUTYL)-1H-PYRROL-3-YL](PHENYL)METHANONE FROM TOSYLMETHYL ISOCYANIDE AND CARBONYL COMPOUND

Kapil Kumar
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Abstract


An efficient one-pot synthetic procedure for [4-(tert-butyl)-1H-pyrrol-3-yl](phenyl)methanone was elaborated using acetophenone and trimethylacetaldehyde in the presence of TosMIC and mild base LiOH·H2O. This method is very economical for the synthesis of pyrrole derivatives and was successfully utilized with good yields.


Keywords


lithium hydroxide, pyrrole, TosMIC, cycloaddition.

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