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AN IMPROVED SYNTHESIS OF 4-CHLORO-7H-PYRROLO[2,3-d]PYRIMIDINE

Yu Luo
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Abstract


An improved seven-step synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7H-pyrrolo[2,3-d]pyrimidine building block.


Keywords


pyrimidine, Janus kinase inhibitor, ozonolysis, synthesis.

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv