FORMATION OF 3,4,5,6-TETRAHYDROQUINAZOLIN-2(1<i>H</i>)-ONE DERIVATIVES IN REACTION OF 4-ARYL-6-METHYL-3,4-DIHYDROPYRIMIDIN-2(1<i>H</i>)-ONES WITH CHALCONES

Authors

  • М. А. Колосов V. N. Karazin Kharkiv National University
  • О. Г. Кулык V. N. Karazin Kharkiv National University
  • О. И. Старченко V. N. Karazin Kharkiv National University
  • В. Д. Орлов V. N. Karazin Kharkiv National University

DOI:

https://doi.org/10.1007/456

Keywords:

1, 3-C, C-bis-nucleophiles, 3, 4-dihydropyrimidin-2(1H)-ones, 4, 5, 6-tetrahydroquinazolin-2(1H)-ones, Biginelli compounds, deacylation

Abstract

A procedure for the preparation of 6-methyl-3,4-dihydropyrimidin-2(1H)-ones involving deacylation of 5-acetyl-6-methyl-3,4-dihydropyrimidin-2(1H)-ones in MeOH–KOH medium is developed. We have shown that the obtained compounds readily undergo reaction with chalcones in MeOH–MeONa with the formation of derivatives of 4,5,7-triaryl-3,4,5,6-tetrahydroquinazolin-2(1H)-one.

Authors: M. A. Kolosov, O. G. Kulyk, O. I. Starchenko, and V. D. Orlov.

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (8), pp 1166-1171

http://link.springer.com/article/10.1007/s10593-013-1359-1

Author Biographies

М. А. Колосов, V. N. Karazin Kharkiv National University

Максим Александрович Колосов

доцент кафедры органической химии ХНУ имени В.Н.Каразина

О. Г. Кулык, V. N. Karazin Kharkiv National University

Олеся Кулык

аспирант кафедры органической химии ХНУ имени В.Н.Каразина

О. И. Старченко, V. N. Karazin Kharkiv National University

Оксана Старченко

магистр кафедры органической химии ХНУ имени В.Н.Каразина

В. Д. Орлов, V. N. Karazin Kharkiv National University

Валерий Дмитриевич Орлов

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Published

2013-06-17

Issue

No. 8 (2013)

Section

Original Papers