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EFFECTIVE SYNTHESIS OF 7H-1,2,4-TRIAZOLO[3,4-b][1,3,4]THIADIAZINES

Нина Николаевна Махова, Александр Сергеевич Куликов, Маргарита Алексеевна Епишина, Леонид Леонидович Ферштат
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Abstract


A highly effective method for the preparation of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines was developed on the basis of condensation reaction between aryl(hetaryl) α-bromo ketones and commercially available thiocarbohydrazide, followed by treatment of the obtained 2-hydrazinyl-6H-1,3,4-thiadiazine hydrobromides with ortho esters in the presence of trifluoroacetic acid under mild conditions.

Keywords


α-bromo ketones, hydrazinylthiadiazines, ortho esters, thiocarbohydrazide, 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines, condensation.

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