SYNTHESIS OF 5-HYDROXY- AND 5-SULFANYL-SUBSTITUTED [1,2,3]TRIAZOLO[4,5-e][1,4]DIAZEPINES

Abstract

5-Amino-N-(2,2-dimethoxyethyl)-1Н-1,2,3-triazole-4-carboxamides in formic acid were subjected to intramolecular cyclization to 5hydroxy[1,2,3]triazolo[4,5-е][1,4]diazepines, which were converted by treatment with S-nucleophiles to 5-thio-functionalized derivatives.

Authors: Sergiy V. Kemskiy, Natalia A. Syrota*, Andriy V. Bol'but, Viktor I. Dorokhov, Mykhaylo V. Vovk