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STUDIES ON QUINAZOLINES 7*. ALKYLATION OF 2-ARYL-4,4-DIPHENYL-3,4-DIHYDROQUINAZOLINES WITH METHYL IODIDE

Геннадий Д. Крапивин, Елена В. Громачевская, Елена А. Кайгородова, Леонид Д. Конюшкин
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Abstract


The reaction of 2-aryl-4,4-diphenyl-3,4-dihydroquinazoline with methyl iodide in acetone in the presence of potassium hydroxide at 40°C leads to the formation of the corresponding 1-methyl-4,4-diphenyl-1,4-dihydroquinazolines and 1,3-dimethyl-4,4-diphenyl-1,4-dihydroquinazolin-
3-ium iodides. The structure of 2-(7-methoxy-1,3-benzodioxol-5-yl)-1-methyl-4,4-diphenyl-1,4-dihydroquinazoline was established by heteronuclear correlation NMR spectroscopy.

Keywords


1,3-dimethyl-4,4-diphenyl-1,4-dihydroquinazolin-3-ium iodides, 1-methyl-4,4-diphenyl-1,4-dihydroquinazolines, methyl iodide, alkylation.

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