REACTION OF ACYLPYRUVIC ACID ESTERS WITH HYDRAZIDES

Abstract

Hydrazides reacted with acylpyruvic acid esters possessing a terminal straight chain alkyl substituent at the C=O bond distal from the ester group, giving 5-hydroxy-2-pyrazolines. Acylpyruvates with bulky terminal substituents underwent condensation at the C=O bond adjacent to the ester group, giving products with hydrazone or 5-hydroxy-2-pyrazoline structure and capable of displaying ring-chain equilibrium between these tautomers in solution.

Authors: V. V. Pakal'nis, I. V. Zerova, S. I. Yakimovich, and V. V. Alekseyev

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (3), pp 408-416

http://link.springer.com/article/10.1007/s10593-013-1261-x