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7-(2-ETHOXYPHENYL)DIHYDROAZOLOPYRIMIDINES IN OXIDATION REACTIONS WITH BROMINE

Ирина Г. Овчинникова, Ольга В. Федорова, Геннадий Л. Русинов, Валерий Н. Чарушин
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Abstract


This study was focused on the oxidation reactions of 4,7- and 6,7-dihydroazolo[1,5-а]pyrimidines with bromine and mechanisms for such reactions were proposed. The effects of ethoxyphenyl substituent and azole ring on the reaction kinetics were demonstrated. The structures of the main products and intermediates of bromination and oxidation reactions were confirmed by 1H NMR spectroscopy, GCMS analysis, and X-ray structural analysis. It was established that the noticeable tuberculostatic activity of azolo[1,5-а]pyrimidines became considerably weaker in the case of their brominated analogs.

Authors: Irina G. Ovchinnikova*, Olga V. Fedorova, Gennady L. Rusinov, Valery N. Charushin


Keywords


brominated derivatives of azolo(azido)pyrimidines; bromination; oxidation with bromine

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