

EFFICIENT SYNTHESIS OF SUBSTITUTED 8-(PYRAZOLO[3,4-d]PYRIMIDIN-6-YL)-1,2-DIHYDROQUINOLINES

Abstract
An effective method for the synthesis of 8-(1-aryl-4-methoxy-1Н-pyrazolo[3,4-d]pyrimidin-6-yl)-2,2,4-trimethyl-1,2-dihydroquinolines was developed on the basis of a three-component reaction between substituted 4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones and 5-amino-1-aryl-1H-pyrazole-4-carbonitriles in refluxing methanol in the presence of an excess of sodium methoxide. HPLC-MS analysis showed that the cascade process started by addition of methanol molecule to the nitrile group of aminopyrazolecarbonitrile.
Authors: Svetlana M. Medvedeva, Yevgeniya A. Kosheleva, Mariya A. Berdnikova, Khidmet S. Shikhaliev*
Keywords
5-aminopyrazole-4-carbonitrile; pyrazolo[3,4-d]pyrimidine; 8-(1Н-pyrazolo[3,4-d]pyrimidin-6-yl)-1,2-dihydroquinoline; pyrrolo[3,2,1-ij]quinoline-1,2-dione; 2,2,4-trimethyl-1,2-dihydroquinoline; hybrid molecules
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv