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MICROWAVE-ASSISTED CU-CATALYZED C–C BOND FORMATION: ONE-POT SYNTHESIS OF FULLY SUBSTITUTED 1,2,3-TRIAZOLES USING NONSYMMETRICAL IODOALKYNES AND THEIR BIOLOGICAL EVALUATION

Nagavelli Vasudeva Reddy, Sirassu Narsimha, Kumaraswamy Battula, Yellu Narsimha Reddy
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Abstract


A copper-catalyzed one-pot synthesis of fused benzothiazino[1,2,3]triazolo[4,5-c]quinolinone derivatives from 1-iodoalkynes with different aryl azides via an in situ generated 5-iodotriazole intermediate in [BMIM]PF6 under microwave irradiation is reported. The reaction provided the desired fused 1,2,3-triazoles in good to excellent yields. Anticancer activity of the synthesized compounds has been screened in vitro against different cancer cell lines (MCF-7, HeLa, A-549, and IMR-32). Some of the derivatives showed remarkable anticancer activity against two cancer cell lines – MCF-7 and A-549. The remaining compounds have shown good to moderate activity against tested cell lines.


Keywords


fused 1,2,3-triazole, ionic liquids, anticancer activity, microwave irradiation.

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