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SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 3-SUBSTITUTED 5-FERROCENYL-1H-PYRAZOLES

Man Ge, Hailian Huang, Xiaofeng Gou, Chengwen Hua, Bang Chen, Junlong Zhao
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Abstract


A convenient method for the selective synthesis of functionalized 3-substituted 5-ferrocenyl-1H-pyrazoles has been developed. Condensation reaction of α,β-unsaturated ferrocenyl ketones and tosylhydrazine in the presence of catalytic amount of iron(III) phthalocyanine chloride allowed to obtain nine new 3-substituted 5-ferrocenyl-1H-pyrazoles. The synthesized products were evaluated for their antifungal activity against Gibberella nicotiancola, Fusarium oxysporum f. sp. niveum, and Gibberella saubinetii. Most of the compounds exhibited excellent antifungal activity.

 


Keywords


ferrocene; iron(III) phthalocyanine chloride; pyrazole; antifungal activity

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