SYNTHESIS AND PROPERTIES OF 6,6-DI(INDOL-3-YL)INDOLO[2,1-<i>b</i>]QUINAZOLIN-12(6<i>H</i>)-ONE AND ITS 2,8-DIMETHYL AND 2,8-DIBROMO DERIVATIVES

Authors

  • Т. В. Московкина Дальневосточный федеральный университет
  • А. И. Калиновский Тихоокеанский институт биоорганической химии им. Г. Б. Елякова ДВО РАН
  • E. А. Мартыяс Тихоокеанский институт биоорганической химии им. Г. Б. Елякова ДВО РАН
  • М. М. Анисимов Тихоокеанский институт биоорганической химии им. Г. Б. Елякова ДВО РАН

DOI:

https://doi.org/10.1007/473

Keywords:

indole, indolo[2, 1-b]quinazolines, antimicrobial action, condensation, fluorescence

Abstract

The condensation of tryptanthrin, as well as its 2,8-dimethyl and 2,8-dibromo derivatives with indole gave previously unreported 6,6-di(indol-3-yl)indolo[2,1-b]quinazolin-12(6H)-ones. 2,8-Disubstituted tryptanthrins and 6,6-di(indol-3­-yl)indolo[2,1-b]quinazolin-12(6H)-one were shown to inhibit Candida albicans KMM 455. Solutions of tryptanthrin itself and its 6,6-diindolyl derivative upon the absorption of light at 434 and 340 nm exhibited fluorescence maxima at λmax 525 and 500 nm, respectively.

Authors: T. V. Moskovkina, A. I. Kalinovskii, E. A. Martyyas, and M. M. Anisimov

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (3), pp 452-456

http://link.springer.com/article/10.1007/s10593-013-1267-4

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Published

2013-04-09

Issue

No. 3 (2013)

Section

Original Papers