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SYNTHESIS AND FUNGICIDAL ACTIVITY OF MONOCYCLIC AND FUSED 1,2,3-TRIAZOLIUM-5-OLATES

Инна С. Хажиева, Павел М. Демкин, Олег С. Ельцов, Юлия И. Нейн, Татьяна А. Калинина, Жи-Джин Фан, Лай Чен, Бин Жао, Татьяна В. Глухарева, Юрий Ю. Моржерин
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Abstract


4-Acetyl-3-(2-aryl-2-oxoethyl)-1-phenyl-1Н-1,2,3-triazol-3-ium-5-olates, as well as 4-hydroxy-, 4-acetoxy-, and 4-amino derivatives of 2,6-diaryl-2H-[1,2,3]triazolо[1,5-а]pyridin-8-ium-3-olates were synthesized and tested for fungicidal activity against 9 strains of phytopathogenic fungi. Some compounds were identified that significantly inhibited the growth of one or several fungal strains. It was found that 4-acetyl-3-[2-(4-chlorophenyl)-2-oxoethyl]-1-phenyl-1Н-1,2,3-triazol-3-ium-5-olate had the best antifungal properties with the median effective concentration in the range of 2.28–47.75 µg/ml.

Authors: Inna S. Khazhieva, Pavel M. Demkin, Oleg S. Eltsov, Yulia I. Nein, Tatiana A. Kalinina, Zhi-Jin Fan, Lai Chen, Bin Zhao,
Tatiana V. Glukhareva, Yuri Yu. Morzherin

 


Keywords


enamines; pyridinium; 1,2,3-triazoles; 1,2,3-triazolium-5-olates; crotonic condensation; antifungal properties; fungicidal activity; phytopathogenic fungi

Full Text: PDF (Russian) Supplementary File(s): Supporting information (5MB)


 

 

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