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DIASTEREOSELECTIVE SYNTHESIS OF 1,2,3-TRIAZOLINES FUSED WITH PENTANE AND DIHYDROPYRAN RINGS

Николай A. Беляев, Татьяна B. Березкина, Василий А. Бакулев, Олег C. Ельцов, Герт Любек
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Abstract


As a result of studying the reactions of 5-azido-1-methyl-4-nitroimidazole and 2,4,5-trimethoxy-1,3,5-triazine with endocyclic enamines, a diastereoselective method was developed for the synthesis of 1-hetarylcycloalkano[1,2,3]triazolines with cis configuration of substituents at the bridgehead carbon atoms. The structures of the obtained reaction products were studied by methods of NMR spectroscopy, high-resolution mass spectrometry, and X-ray structural analysis.

Authors: Nikolay A. Belyaev, Tetyana V. Beryozkina, Vasiliy A. Bakulev*,
Oleg S. Eltsov, Gert Lubec


Keywords


azide; enamine; imidazole; triazine; triazoline

Full Text: PDF (Russian) Supplementary File(s): Supporting information (1MB)


 

 

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