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SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3,5-DIACETYL-2,6-DIMETHYLPYRIDINE DERIVATIVES

Алена Л. Олещук, Анастасия А. Карбаинова, Татьяна Н. Криворучко, Зарина Т. Шульгау, Тулеген М. Сейлханов, Иван Вячеславович Кулаков
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Abstract


Aldol-crotonic condensation reactions of 3,5-diacetyl-2,6-dimethylpyridine with various aldehydes were used to synthesize bisazachalcone derivatives, which were subsequently cyclized with hydrazine hydrate in acetic acid, leading to the respective bisderivatives of 4,5-dihydro-1H-pyrazole. The reactions of 3,5-diacetyl-2,6-dimethylpyridine with some hydrazides also provided the respective bishydrazones. The analgesic activity of the obtained derivatives was tested.

Keywords


bisazachalcones, 3,5-diacetyl-2,6-dimethylpyridine, hydrazones, pyrazolines, analgesic activity.

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