

SYNTHESIS OF β-(o-HYDROXYBENZYL)PYRIDINES BY THREE-COMPONENT CONDENSATION OF AMMONIA, CARBONYL-SUBSTITUTED 4Н-CHROMENES, AND СН ACIDS

Abstract
A series of pyridine derivatives containing a 2-hydroxybenzyl or (2-hydroxynaphthalen-1-yl)methyl substituent were obtained by treating
carbonyl-substituted 4Н-chromenes and 1Н-benzo[f]chromenes with ammonia and 1,3-dicarbonyl compounds or aromatic ketones as a result of the carbo-Michael reaction, chromane ring opening, and cyclodehydration.
carbonyl-substituted 4Н-chromenes and 1Н-benzo[f]chromenes with ammonia and 1,3-dicarbonyl compounds or aromatic ketones as a result of the carbo-Michael reaction, chromane ring opening, and cyclodehydration.
Keywords
3-acyl-4Н-chromenes, 1,3-dicarbonyl compounds, 7,8-dihydroquinolin-5(6Н)-ones, enaminones, Michael reaction, multicomponent reactions.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv