SYNTHESIS OF β-( o -HYDROXYBENZYL)PYRIDINES BY THREE-COMPONENT CONDENSATION OF AMMONIA, CARBONYL-SUBSTITUTED 4 Н -CHROMENES, AND СН ACIDS

Дмитрий В. Осипов; Виталий А. Осянин; Юрий Н. Климочкин

doi:10.1007/4766

SYNTHESIS OF β-(o-HYDROXYBENZYL)PYRIDINES BY THREE-COMPONENT CONDENSATION OF AMMONIA, CARBONYL-SUBSTITUTED 4Н-CHROMENES, AND СН ACIDS

Дмитрий В. Осипов, Виталий А. Осянин, Юрий Н. Климочкин

Abstract

A series of pyridine derivatives containing a 2-hydroxybenzyl or (2-hydroxynaphthalen-1-yl)methyl substituent were obtained by treating
carbonyl-substituted 4Н-chromenes and 1Н-benzo[f]chromenes with ammonia and 1,3-dicarbonyl compounds or aromatic ketones as a result of the carbo-Michael reaction, chromane ring opening, and cyclodehydration.

Keywords

3-acyl-4Н-chromenes, 1,3-dicarbonyl compounds, 7,8-dihydroquinolin-5(6Н)-ones, enaminones, Michael reaction, multicomponent reactions.

Full Text: PDF (Russian) Open Access

Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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