SYNTHESIS OF NOVEL SPIRO-CONDENSED 2-AMINO-4 H -PYRANS BASED ON 1,2-BENZOXATHIIN-4(3 H )-ONE 2,2-DIOXIDE

Galina V. Grigoriv; Dmitry A. Lega; Lucjusz Zaprutko; Andrzej K. Gzella; Ewa Wieczorek-Dziurla; Valentine P. Chernykh; Leonid A. Shemchuk

doi:10.1007/4772

SYNTHESIS OF NOVEL SPIRO-CONDENSED 2-AMINO-4H-PYRANS BASED ON 1,2-BENZOXATHIIN-4(3H)-ONE 2,2-DIOXIDE

Galina V. Grigoriv, Dmitry A. Lega, Lucjusz Zaprutko, Andrzej K. Gzella, Ewa Wieczorek-Dziurla, Valentine P. Chernykh, Leonid A. Shemchuk

Abstract

A series of new spiro-condensed 2-amino-4H-pyrans were synthesized by three-component interaction of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide, malononitrile, and cyclic carbonyls in moderate to high yields. This is one of the first examples of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide application in multicomponent transformations.

Keywords

active methylene nitrile; 1,2-benzoxathiin-4(3H)-one 2,2-dioxide; isatin; ninhydrin; spiro compounds; multicomponent reactions

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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